NosA, a transcription factor important in Aspergillus fumigatus stress and developmental response, rescues the germination defect of a laeA deletion.

@article{Soukup2012NosAAT,
  title={NosA, a transcription factor important in Aspergillus fumigatus stress and developmental response, rescues the germination defect of a laeA deletion.},
  author={Alexandra A Soukup and Mitra Farnoodian and Erwin Berthier and Nancy P Keller},
  journal={Fungal genetics and biology : FG & B},
  year={2012},
  volume={49 11},
  pages={857-65}
}
Aspergillus fumigatus is an increasingly serious pathogen of immunocompromised patients, causing the often fatal disease invasive aspergillosis (IA). One A. fumigatus virulence determinant of IA is LaeA, a conserved virulence factor in pathogenic fungi. To further understand the role of LaeA in IA, the expression profile of ΔlaeA was compared to wild type, and several transcription factors were found significantly misregulated by LaeA loss. One of the transcription factors up-regulated over 4… CONTINUE READING
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