Norzotepine, a Major Metabolite of Zotepine, Exerts Atypical Antipsychotic-Like and Antidepressant-Like Actions through Its Potent Inhibition of Norepinephrine Reuptake

  title={Norzotepine, a Major Metabolite of Zotepine, Exerts Atypical Antipsychotic-Like and Antidepressant-Like Actions through Its Potent Inhibition of Norepinephrine Reuptake},
  author={Miwako Shobo and Yuji Kondo and H. Yamada and Takuma Mihara and Noriyuki Yamamoto and Masayuki Katsuoka and Katsuya Harada and K Ni and N. Matsuoka},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={772 - 781}
  • M. Shobo, Y. Kondo, N. Matsuoka
  • Published 1 June 2010
  • Biology, Psychology, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
The antipsychotic drug zotepine [ZTP; 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethylethan-1-amine] is known to have not only atypical antipsychotic effects but also antidepressive effects in schizophrenia patients. Norzotepine [norZTP; N-desmethylzotepine, 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N-methylethan-1-amine] has been postulated to be a major metabolite of ZTP in humans. Here, we characterized norZTP through several in vitro studies and in animal models of psychosis… 

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