Norsolorinic acid from Aspergillus nidulans inhibits the proliferation of human breast adenocarcinoma MCF-7 cells via Fas-mediated pathway.

Abstract

Norsolorinic acid, isolated from the Aspergillus nidulans, was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. To identity the anticancer mechanism of norsolorinic acid, we assayed its effect on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO-1 receptor and Fas ligand. The results showed… (More)
DOI: 10.1111/j.1742-7843.2008.00237.x

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@article{Wang2008NorsolorinicAF, title={Norsolorinic acid from Aspergillus nidulans inhibits the proliferation of human breast adenocarcinoma MCF-7 cells via Fas-mediated pathway.}, author={Clay Chia Chun Wang and Yi-Ming Chiang and Po-Lin Kuo and J Chang and Ya-Ling Hsu}, journal={Basic & clinical pharmacology & toxicology}, year={2008}, volume={102 6}, pages={491-7} }