Norrin treatment improves ganglion cell survival in an oxygen-induced retinopathy model of retinal ischemia.

Abstract

Treatment of a mouse model of oxygen-induced retinopathy (OIR) with recombinant human Norrin (Norrie Disease Protein, gene: NDP) accelerates regrowth of the microvasculature into central ischemic regions of the neural retina, which are generated after treatment with 75% oxygen. While this reduces the average duration and severity of ischemia overall, we do… (More)
DOI: 10.1016/j.exer.2017.08.012

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