Norovirus GII.4 strain antigenic variation.

@article{Lindesmith2011NorovirusGS,
  title={Norovirus GII.4 strain antigenic variation.},
  author={Lisa C Lindesmith and Eric F. Donaldson and Ralph S. Baric},
  journal={Journal of virology},
  year={2011},
  volume={85 1},
  pages={
          231-42
        }
}
Noroviruses are the principal cause of epidemic gastroenteritis worldwide. Multiple reports have concluded that the major capsid proteins of GII.4 strains, which cause 80% of norovirus infections worldwide, are evolving rapidly, resulting in new epidemic strains. Surrogate neutralization assays using sera from outbreaks and from immunized mice suggest that, as with influenza virus, antigenic variation maintains GII.4 persistence in the face of human population herd immunity. To test this… CONTINUE READING

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