Normoxic induction of the hypoxic-inducible factor-1 alpha by interleukin-1 beta involves the extracellular signal-regulated kinase 1/2 pathway in normal human cytotrophoblast cells.

@article{Qian2004NormoxicIO,
  title={Normoxic induction of the hypoxic-inducible factor-1 alpha by interleukin-1 beta involves the extracellular signal-regulated kinase 1/2 pathway in normal human cytotrophoblast cells.},
  author={Dong Qian and Hai-yan Lin and H Wang and Xuan Zhang and Dong-lin Liu and Qing-lei Li and Cheng Zhu},
  journal={Biology of reproduction},
  year={2004},
  volume={70 6},
  pages={
          1822-7
        }
}
During early pregnancy, an environment of relative low oxygen tension is essential for normal embryonic and placental vasculature. In low-oxygen conditions, the hypoxic-inducible factor-1 (HIF-1), composed of alpha and beta subunits, controls the expression of a number of genes such as vascular endothelial growth factor (VEGF), a key angiogenic factor. The recent studies in some tumor cells have found that the labile component, HIF-1 alpha, is not only activated by hypoxia but also by peptides… CONTINUE READING

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