Normoxic induction of cerebral HIF-1alpha by acetazolamide in rats: role of acidosis.


Acetazolamide has been recognized as an effective treatment for acute mountain sickness. The efficacy of acetazolamide is related to metabolic acidosis, which promotes chemoreceptors to respond to hypoxic stimuli at altitude. In this study, adult male Sprague-Dawley rats were treated with acetazolamide (100mg/kg or 50mg/kg, I.P.) for 3 days. Primary… (More)
DOI: 10.1016/j.neulet.2009.01.008