Normothermic preservation of the rat hind limb with artificial oxygen-carrying hemoglobin vesicles.

@article{Araki2015NormothermicPO,
  title={Normothermic preservation of the rat hind limb with artificial oxygen-carrying hemoglobin vesicles.},
  author={Junichi Araki and Hiromi Sakai and Dan Takeuchi and Yu Kagaya and Kensuke Tashiro and Munekazu Naito and Makoto Mihara and Mitsunaga Narushima and Takuya Iida and Isao Koshima},
  journal={Transplantation},
  year={2015},
  volume={99 4},
  pages={
          687-92
        }
}
BACKGROUND For managing major limb amputation, it is important to consider ischemic time and reperfusion injury by free radicals after the blood supply is reestablished. State of preservation during transplant surgery is crucial for the survival and function of the tissue, graft, or organ. In this study, we confirmed the effect of intermittent blood flow in rat ischemic hind limb and developed a new oxygenic preservation method using artificial oxygen carrying hemoglobin vesicles (HbVs… CONTINUE READING
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