Normothermic ex vivo lung perfusion in clinical lung transplantation.

  title={Normothermic ex vivo lung perfusion in clinical lung transplantation.},
  author={Marcelo Cypel and Jonathan Chi-Wai Yeung and Ming-yao Liu and Masaki Anraku and Fengshi Chen and Wojtek Karolak and Masaaki Sato and Jane Laratta and Sassan Azad and M Madonik and Chung-Wai Chow and Cecilia Chaparro and Michael J. Hutcheon and Lianne G Singer and Arthur S Slutsky and Kazuhiro Yasufuku and Marc E de Perrot and Andrew F. Pierre and Thomas K Waddell and Shaf Keshavjee},
  journal={The New England journal of medicine},
  volume={364 15},
BACKGROUND More than 80% of donor lungs are potentially injured and therefore not considered suitable for transplantation. With the use of normothermic ex vivo lung perfusion (EVLP), the retrieved donor lung can be perfused in an ex vivo circuit, providing an opportunity to reassess its function before transplantation. In this study, we examined the feasibility of transplanting high-risk donor lungs that have undergone EVLP. METHODS In this prospective, nonrandomized clinical trial, we… CONTINUE READING
Twitter Mentions


Publications referenced by this paper.

Construct validity of the definition of primary graft dysfunction after lung transplantation.

Initial experience with lung donation after cardiocirculatory death in Canada

  • M Cypel, M Sato, E Yildirim
  • J Heart Lung Transplant
  • 2009

Lung donor selection and management.

Normothermic ex vivo perfusion prevents lung injury compared to extended cold preservation for transplantation.

  • Marcelo Cypel, Matthew Rubacha, +10 authors Shaf Keshavjee
  • Medicine
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2009

Early lung transplantation success utilizing controlled donation after cardiac death donors.