Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.

@article{Tolias2004NormobaricHI,
  title={Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.},
  author={Christos Michael Tolias and Michael Reinert and Rolf Seiler and Charlotte Perkins Gilman and Alexander Scharf and Malcolm Ross Bullock},
  journal={Journal of neurosurgery},
  year={2004},
  volume={101 3},
  pages={435-44}
}
OBJECT The effect of normobaric hyperoxia (fraction of inspired O2 [FIO2] concentration 100%) in the treatment of patients with traumatic brain injury (TBI) remains controversial. The aim of this study was to investigate the effects of normobaric hyperoxia on five cerebral metabolic indices, which have putative prognostic significance following TBI in humans. METHODS At two independent neurointensive care units, the authors performed a prospective study of 52 patients with severe TBI who were… CONTINUE READING

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