Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

@article{Nishikawa2000NormalizingMS,
  title={Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage},
  author={T. Nishikawa and D. Edelstein and Xue-liang Du and S. Yamagishi and T. Matsumura and Y. Kaneda and M. Yorek and D. Beebe and P. Oates and H. Hammes and I. Giardino and M. Brownlee},
  journal={Nature},
  year={2000},
  volume={404},
  pages={787-790}
}
Diabetic hyperglycaemia causes a variety of pathological changes in small vessels, arteries and peripheral nerves. Vascular endothelial cells are an important target of hyperglycaemic damage, but the mechanisms underlying this damage are not fully understood. Three seemingly independent biochemical pathways are involved in the pathogenesis: glucose-induced activation of protein kinase C isoforms; increased formation of glucose-derived advanced glycation end-products; and increased glucose flux… Expand
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