Normalizing GDNF expression in the spinal cord alleviates cutaneous hyperalgesia but not ongoing pain in a rat model of bone cancer pain.

@article{Ding2017NormalizingGE,
  title={Normalizing GDNF expression in the spinal cord alleviates cutaneous hyperalgesia but not ongoing pain in a rat model of bone cancer pain.},
  author={Zhuofeng Ding and Wei Xu and Jie Zhang and Wangyuan Zou and Qulian Guo and Changsheng Huang and Chang Liu and Tao Zhong and Jun-Ming Zhang and Zongbin Song},
  journal={International journal of cancer},
  year={2017},
  volume={140 2},
  pages={411-422}
}
Bone cancer pain (BCP) is the most common complication in patients with bone cancer. Glial cell line-derived neurotrophic factor (GDNF) is believed to be involved in chronic pain conditions. In this article, the expression and roles of GDNF were studied in a rat model of BCP induced by tibia injection of Walker 256 rat mammary gland carcinoma cells. Significant mechanical and thermal hyperalgesia and ongoing pain were observed beginning as early as day 5 post injection. The expression level of… CONTINUE READING