Normalization of two-channel microarray experiments: a semiparametric approach

@article{Eckel2005NormalizationOT,
  title={Normalization of two-channel microarray experiments: a semiparametric approach},
  author={J. E. Eckel and C. Gennings and Terry M. Therneau and L. D. Burgoon and D. R. Boverhof and T. R. Zacharewski},
  journal={Bioinformatics},
  year={2005},
  volume={21 7},
  pages={1078-83}
}
MOTIVATION An important underlying assumption of any experiment is that the experimental subjects are similar across levels of the treatment variable, so that changes in the response variable can be attributed to exposure to the treatment under study. This assumption is often not valid in the analysis of a microarray experiment due to systematic biases in… CONTINUE READING