Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization.

  title={Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization.},
  author={Malin E V Johansson and Hedvig E Jakobsson and Jessica M. Holm{\'e}n-Larsson and Andr{\'e} Sch{\"u}tte and Anna Ermund and Ana Mar{\'i}a Rodr{\'i}guez-Pi{\~n}eiro and Liisa Arike and Catharina Wising and Frida R. Svensson and Fredrik B{\"a}ckhed and Gunnar C Hansson},
  journal={Cell host & microbe},
  volume={18 5},
The intestinal mucus layer provides a barrier limiting bacterial contact with the underlying epithelium. Mucus structure is shaped by intestinal location and the microbiota. To understand how commensals modulate gut mucus, we examined mucus properties under germ-free (GF) conditions and during microbial colonization. Although the colon mucus organization of GF mice was similar to that of conventionally raised (Convr) mice, the GF inner mucus layer was penetrable to bacteria-sized beads. During… CONTINUE READING


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