Normal tyrosine transport and abnormal tyrosinase routing in pink-eyed dilution melanocytes.

@article{Potterf1998NormalTT,
  title={Normal tyrosine transport and abnormal tyrosinase routing in pink-eyed dilution melanocytes.},
  author={S. Brian Potterf and Minao Furumura and Elena V Sviderskaya and Claudio De Santis and Dorothy C Bennett and Vincent J. Hearing},
  journal={Experimental cell research},
  year={1998},
  volume={244 1},
  pages={319-26}
}
The pink-eyed dilution phenotype in mice arises from mutations in the p gene; in humans, analogous mutations in the P gene result in oculocutaneous albinism type 2. Although the molecular mechanisms which underlie this phenotype remain obscure, it has been postulated that mutations in p result in defective tyrosine transport into murine melanosomes, resulting in hypopigmentation and diminished coat color. However, we previously reported no difference in melanosomal tyrosine transport in… CONTINUE READING