Normal tissue complication probability estimation by the Lyman-Kutcher-Burman method does not accurately predict spinal cord tolerance to stereotactic radiosurgery.

@article{Daly2012NormalTC,
  title={Normal tissue complication probability estimation by the Lyman-Kutcher-Burman method does not accurately predict spinal cord tolerance to stereotactic radiosurgery.},
  author={Megan Eileen Daly and Gary Luxton and Clara Y H Choi and Iris C. Gibbs and Steven D Chang and John R. Adler and Scott Soltys},
  journal={International journal of radiation oncology, biology, physics},
  year={2012},
  volume={82 5},
  pages={2025-32}
}
PURPOSE To determine whether normal tissue complication probability (NTCP) analyses of the human spinal cord by use of the Lyman-Kutcher-Burman (LKB) model, supplemented by linear-quadratic modeling to account for the effect of fractionation, predict the risk of myelopathy from stereotactic radiosurgery (SRS). METHODS AND MATERIALS From November 2001 to July 2008, 24 spinal hemangioblastomas in 17 patients were treated with SRS. Of the tumors, 17 received 1 fraction with a median dose of 20… CONTINUE READING

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