Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1.


The process of learning involves stable changes in synaptic efficacy for which long-term potentiation (LTP) provides a widely adopted mammalian model. Synaptic modification induced by learning or LTP may involve the action of cell adhesion molecules. One such candidate is the ubiquitous neuronal glycoprotein Thy-1. In mice in which the gene encoding Thy-1 has been inactivated, we find a regionally selective impairment of LTP in vivo in the hippocampal formation: LTP is normal in area CA1 but strongly inhibited in the dentate gyrus. Spatial learning by Thy-1-deficient mice, as assessed in the watermaze, is unimpaired. Thus LTP in the cortical input to the dentate gyrus seems not to be required for spatial learning.

Citations per Year

685 Citations

Semantic Scholar estimates that this publication has 685 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{NostenBertrand1996NormalSL, title={Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1.}, author={Marika Nosten-Bertrand and Mick L. Errington and Kerry P. S. J. Murphy and Yoshihiro Tokugawa and Erminia A.M. Barboni and E. Kozlova and David Michalovich and Robin G. Morris and Justin Silver and Colin Lawson Stewart and Timothy V.P. Bliss and Rohinton J. Morris}, journal={Nature}, year={1996}, volume={379 6568}, pages={826-9} }