Normal reproductive capacity of heifers that originated from in vitro fertilized embryos cultured with an antiviral compound.

@article{Givens2009NormalRC,
  title={Normal reproductive capacity of heifers that originated from in vitro fertilized embryos cultured with an antiviral compound.},
  author={M. Givens and M. Marley and K. Riddell and P. Galik and D. Stringfellow},
  journal={Animal reproduction science},
  year={2009},
  volume={113 1-4},
  pages={
          283-6
        }
}
  • M. Givens, M. Marley, +2 authors D. Stringfellow
  • Published 2009
  • Biology, Medicine
  • Animal reproduction science
  • Bovine viral diarrhea virus (BVDV) can associate with in vitro fertilized (IVF) bovine embryos despite washing and trypsin treatment. An antiviral compound, DB606 (2-(4-[2-imidazolinyl]phenyl)-5-(4-methoxyphenyl)furan), inhibits the replication of BVDV in bovine uterine tubal epithelial cells, Madin Darby bovine kidney cells, and fetal fibroblast cells. As well, DB606 in in vitro culture medium does not affect embryonic development. Antiviral-treated-IVF embryos placed into recipients developed… CONTINUE READING
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