Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice.

@article{Zhang2001NormalPB,
  title={Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice.},
  author={Fu-ping Zhang and Marjo Poutanen and Johannes H Wilbertz and I lpo Huhtaniemi},
  journal={Molecular endocrinology},
  year={2001},
  volume={15 1},
  pages={172-83}
}
To study further the role of gonadotropins in reproductive functions, we generated mice with LH receptor (LHR) knockout (LuRKO) by inactivating, through homologous recombination, exon 11 on the LHR gene. LuRKO males and females were born phenotypically normal, with testes, ovaries, and genital structures indistinguishable from their wild-type (WT) littermates. Postnatally, testicular growth and descent, and external genital and accessory sex organ maturation, were blocked in LuRKO males, and… CONTINUE READING

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