[Normal polymorphism of the (CTG)n repeat in the myotonin protein kinase (DM) gene on chromosome 19q13.3 in Western European populations].

Abstract

Polymorphism of a highly polymorphic CTG repeat in the 3'-untranslated region of the myotonin protein kinase gene was analyzed in healthy people from several Eastern European populations (Russians, Moldovans, Belarussians, Komis, Chuvashes, Udmurts, Bashkirs, Tatars, Maris, and Mordovians). In total, 26 alleles of the CTG repeat were found, the repeat number ranging from 5 to 33 (alleles with six and seven repeats were not detected). The heterozygosity of individual populations varied from 61 to 91%. In the total sample combining all populations, the observed and expected heterozygosities did not differ (fixation index -0.0022) suggesting selective neutrality of the normal polymorphism of the CTG repeat in the myotonin protein kinase gene.

Statistics

050010001500'04'05'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

180 Citations

Semantic Scholar estimates that this publication has 180 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Slominski2000NormalPO, title={[Normal polymorphism of the (CTG)n repeat in the myotonin protein kinase (DM) gene on chromosome 19q13.3 in Western European populations].}, author={P A Slominskiĭ and S N Popova and M I Shadrina and M A Pomazanova and T Iu Lomova and R I Fatkhlislamova and E K Khusnutdinova and I A Guseva and Sh Erdes and A I Mikulich and V A Spitsyn and S A Limborskaia}, journal={Genetika}, year={2000}, volume={36 7}, pages={980-5} }