Normal newt limb regeneration requires matrix metalloproteinase function.

  title={Normal newt limb regeneration requires matrix metalloproteinase function.},
  author={Vladimir Vinarsky and Donald L. Atkinson and Tamara J. Stevenson and Mark T. Keating and Shannon Odelberg},
  journal={Developmental biology},
  volume={279 1},
Newts regenerate lost limbs through a complex process involving dedifferentiation, migration, proliferation, and redifferentiation of cells proximal to the amputation plane. To identify the genes controlling these cellular events, we performed a differential display analysis between regenerating and nonregenerating limbs from the newt Notophthalmus viridescens. This analysis, coupled with a direct cloning approach, identified a previously unknown Notophthalmus collagenase gene (nCol) and three… CONTINUE READING