Normal neuroanatomical variation in the human brain: an MRI-volumetric study.

  title={Normal neuroanatomical variation in the human brain: an MRI-volumetric study.},
  author={John S. Allen and Hanna Damasio and Thomas J. Grabowski},
  journal={American journal of physical anthropology},
  volume={118 4},
Normative data on the in vivo size of the human brain and its major anatomically defined subdivisions are not readily available. [] Key Method In this study, high-resolution magnetic resonance imaging was used to measure regional brain volumes in 46 normal, right-handed adults (23 men, 23 women) between the ages of 22-49 years. Parcellation of the brain was based on neuroanatomical landmarks.

Clinical study Cerebral cortex: An MRI-based study of volume and variance with age and sex

This study confirms and augments past work indicating underlying structural asymmetries in the human brain, and provides further evidence that brain structures in humans are differentially sensitive to the effects of both age and sex.

Sexual dimorphism and asymmetries in the gray–white composition of the human cerebrum

Asymmetry of the hippocampus and amygdala in MRI volumetric measurements of normal adults

Meta-analytic procedures employed to provide a systematic analysis of the normal population parameters of hippocampal and amygdala volumetric asymmetry as well as the absolute intrahemispheric volumes of these structures in normal adults revealed that both the hippocampus and the amygdala are reliably asymmetrical structures innormal adults.

Gender-Based Cerebral Perfusion Differences in 46,034 Functional Neuroimaging Scans.

Significant gender differences in a healthy and clinical psychiatric population are demonstrated and may be useful in understanding the epidemiological gender differences among psychiatric disorders.

Selective atrophy of left hemisphere and frontal lobe of the brain in old men.

Elderly men showed significantly greater left hemisphere and left frontal lobe volume losses than did elderly women, indicating that the larger left hemisphere relative volume reduction is largely contributed to by selective atrophy of the left frontal lobes volume in elderly men.

Gender Differences in White Matter Microstructure

The size of the differences was substantial, suggesting gender may be a potentially significant confound in unbalanced clinical studies and the higher FA in women may reflect greater efficiency of a smaller corpus callosum.

Human Sexual Dimorphism of the Relative Cerebral Area Volumes in the Data of the Human Connectome Project

The relative volumes of numerous subcortical areas and the gray matter of most cortical areas are significantly larger in women than in men, and differences of the strengths of the sexual correlations between the same structures in different hemispheres are discovered.

Correlations between Regional Brain Volumes and Memory Performance in Anoxia

A strong quantitative relationship between performance on anterograde memory tests and hippocampal and regional gray matter volume residuals is indicated, which may provide a good indication of clinical outcome in anoxia.



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The results suggest that the size of some cerebral structures may account for a significant, but modest, proportion of the variance in human intelligence.

Sex Differences in Brain Gray and White Matter in Healthy Young Adults: Correlations with Cognitive Performance

Both GM and WM volumes correlated moderately with global, verbal, and spatial performance across groups, however, the regression of cognitive performance and WM volume was significantly steeper in women.

Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging.

A new method to segment the entire neocortex into 48 topographically defined brain regions suggested the importance of the paralimbic areas and their connections with prefrontal brain regions in schizophrenia.

Asymmetries in cerebral width in nonhuman primate brains as revealed by magnetic resonance imaging (MRI)

MRI anatomy of schizophrenia

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Several brain structures in schizophrenia are affected to a greater extent than expected from overall reductions in brain volume, and substantial reductions were also evident in the amygdala and hippocampus.

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These patterns of growth and change seen in vivo with MRI are largely consistent with neuropathological studies, as well as animal models of development, and may reflect neuronal progressive and regressive processes, including cell growth, myelination, cell death, and atrophy.

Quantitative magnetic resonance imaging of brain development in premature and mature newborns

The application of 3D MRI and tissue segmentation to the study of human infant brain from 29 to 41 weeks of postconceptional age has provided new insights into cerebral cortical development and myelination and has for the first time provided means of quantitative assessment in vivo of early human brain development.

The primate neocortex in comparative perspective using magnetic resonance imaging.

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