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Effects of voluntary physical activity and endurance training in cardiac mitochondrial function of high-fat diet-fed rats.
Assessing oral glucose and intravenous insulin loading protocol in 18F-fluorodeoxyglucose positron emission tomography cardiac viability studies
- MedicineWorld journal of nuclear medicine
Assessing if certain parameters, particularly the amount of glucose and insulin given, may affect18F-FDG uptake in the hibernating myocardium and also determining the problems with G/I loading protocol found no significant difference.
Olanzapine-mediated cardiotoxicity is associated with altered energy metabolism in isolated rat hearts.
- Chemistry, MedicineActa biochimica Polonica
Investigation of the effect of acute olanzapine administration on pathways regulating the cardiac energy metabolism in an isolated heart found a trend for lower phosphorylation levels of Akt and its downstream products AS160, a key regulator of GLUT4 trafficking and glycogen synthase kinase‑3ß in olanZapine‑treated hearts when compared to vehicle-treated controls.
Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion
- MedicineExpert review of cardiovascular therapy
This review provides the basis for a number of clinical applications of CCrP and CCr to minimize ischemic injury and necrosis in patients who will undergo cardiopulmonary bypass for coronary revascularization and end-stage heart failure patients scheduled for heart transplantation.
Clinical Significance and Applications of D-Ribose in Cardiovascular Disease
- MedicineInternational Archives of Cardiovascular Diseases
Clinical Significance and applications of D-Ribose in Cardiovascular Disease and its applications are described and described in detail in Bayram et al.
Emerging potential benefits of modulating NAD+ metabolism in cardiovascular disease.
- Chemistry, MedicineAmerican journal of physiology. Heart and circulatory physiology
This review examines the molecular physiology and preclinical data with respect to NAD+ precursors in heart failure-related cardiac remodeling, ischemic-reperfusion injury, and arrhythmias and proposes alternative NAD+-boosting strategies and potential systemic effects of NAD+ supplementation with implications on cardiovascular health and disease.
An investigation into the importance of the ATM protein in the myocardial pathology associated with insulin resistance and type 2 diabetes
The objective was to provide a systematic procedure for estimating the intensity of the response of the immune responses of the central nervous system to certain types of injury.
Impact of age on the association between cardiac high-energy phosphate metabolism and cardiac power in women
Significant positive relationship between PCr:ATP ratio, early-to-late diastolic filling ratio and peak cardiac power output suggests that cardiac high-energy phosphate metabolism may be an important determinant of cardiac function and performance.
Optimized CEST cardiovascular magnetic resonance for assessment of metabolic activity in the heart
- MedicineJournal of Cardiovascular Magnetic Resonance
Lower CEST signal in bright region of the LGE image is consistent with the fact that myocardial infarction has reduced metabolic activity, and the hypointense regions in the CEST contrast maps closely match the bright areas in the L GE images.
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Increased non-esterified fatty acid availability during the clamps decreased pyruvate dehydrogenase activity in liver, heart, adipose tissue and quadriceps muscle, in both groups of rats, consistent with an inhibition of glycolysis in Liver, skeletal muscle and heart by increased fatty acids availability.
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It is suggested that chronic manipulation of myocardial substrate oxidation toward greater carbohydrate oxidation and less fatty acid oxidation may improve ventricular performance and slow the progression of left ventricular dysfunction in heart failure patients.
Human myocardial ATP content and in vivo contractile function
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Declines in the sizes of myocardial ATP, adenine nucleotide, and pyridine nucleotide pools in the human myocardium are associated primarily with diastolic but not systolic dysfunction.
An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics.
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The model closely reproduces experimentally observed mitochondrial NADH dynamics in heart trabeculae subjected to changes in pacing frequency and supports the hypothesis that mitochondrial matrix Ca(2+) plays an important role in matching energy supply with demand in cardiac myocytes.
From energy store to energy flux: a study in creatine kinase deficient fast skeletal muscle
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Two possible patterns of energy transport in muscle cells are demonstrated: energy store with phosphocreatine and energy flux through mitochondria, suggesting a direct ATP/ADP channeling between sites of energy production (mitochondria) and energy utilization in CK−/− mice.
Phosphotransfer networks and cellular energetics
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31P NMR Detection of Subcellular Creatine Kinase Fluxes in the Perfused Rat Heart
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First experimental evidence that the energy is carried from mitochondria to ATPases by PCr (i.e. CK shuttle) in the whole heart is provided, suggesting that cardiac activity modified energy transfer pathways.
A Role for Peroxisome Proliferator-activated Receptor α (PPARα) in the Control of Cardiac Malonyl-CoA Levels
- BiologyThe Journal of Biological Chemistry
It is demonstrated that PPARα is an important regulator of fatty acid oxidation in the heart and that this regulation of fatty acids oxidation may in part occur due to the transcriptional control of malonyl-CoA decarboxylase.
Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopy.
- MedicineJournal of the American College of Cardiology
In human heart failure due to DCM, both PCr and ATP are significantly reduced, andRatios of PCr to ATP underestimate changes of high-energy phosphate levels.