Normal labor associated with changes in uterine heparan sulfate proteoglycan expression and localization.

@article{Cluff2005NormalLA,
  title={Normal labor associated with changes in uterine heparan sulfate proteoglycan expression and localization.},
  author={Ann Hjelm Cluff and Anders Malmstr{\"o}m and Berith K Ting{\aa}ker and Guido David and Gunvor Ekman-Ordeberg},
  journal={Acta obstetricia et gynecologica Scandinavica},
  year={2005},
  volume={84 3},
  pages={217-24}
}
HYPOTHESIS Proteoglycans are well-known modulators of intercellular communication and signaling. Remodeling of the proteoglycans in the human uterus occurs throughout pregnancy, and during labor. We therefore hypothesize that heparan sulfate proteoglycans (HSPGs) play an important role in establishing normal labor. In this study HSPGs were characterized and localized in human uterine tissue. METHODS Uterine biopsies were obtained from four nonpregnant women, four women during elective… CONTINUE READING

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