Normal in vivo skeletal muscle oxidative metabolism in sporadic inclusion body myositis assessed by 31P-magnetic resonance spectroscopy.

@article{Lodi1998NormalIV,
  title={Normal in vivo skeletal muscle oxidative metabolism in sporadic inclusion body myositis assessed by 31P-magnetic resonance spectroscopy.},
  author={Raffaele Lodi and Dianne E. Taylor and Sarah J Tabrizi and D. H. J. Hilton-Jones and MarianV. Squier and Anneke Seller and Peter Styles and Anthony H V Schapira},
  journal={Brain : a journal of neurology},
  year={1998},
  volume={121 ( Pt 11)},
  pages={
          2119-26
        }
}
Sporadic inclusion body myositis (s-IBM) is a chronic inflammatory myopathy of unknown pathogenesis. The common findings of ragged red fibres, cytochrome c oxidase-negative fibres and multiple mitochondrial DNA deletions in the muscle of patients with s-IBM have suggested that a deficit of energy metabolism may be of pathogenic relevance. To test this hypothesis we used 31P magnetic resonance spectroscopy to assess in vivo skeletal muscle mitochondrial function in the calf muscles of 12… CONTINUE READING
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