Normal huntingtin function: an alternative approach to Huntington's disease

@article{Cattaneo2005NormalHF,
  title={Normal huntingtin function: an alternative approach to Huntington's disease},
  author={Elena Cattaneo and Chiara Zuccato and Marzia Tartari},
  journal={Nature Reviews Neuroscience},
  year={2005},
  volume={6},
  pages={919-930}
}
Several neurological diseases are characterized by the altered activity of one or a few ubiquitously expressed cell proteins, but it is not known how these normal proteins turn into harmful executors of selective neuronal cell death. We selected huntingtin in Huntington's disease to explore this question because the dominant inheritance pattern of the disease seems to exclude the possibility that the wild-type protein has a role in the natural history of this condition. However, even in this… 
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