Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endogenous cannabinoids: first evidence for a direct role of cannabinoids on hormone modulation at the human pituitary level.

@article{Pagotto2001NormalHP,
  title={Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endogenous cannabinoids: first evidence for a direct role of cannabinoids on hormone modulation at the human pituitary level.},
  author={Uberto Pagotto and Giovanni Marsicano and Filomena Fezza and Marily Theodoropoulou and Yvonne Gruebler and Johanna Stalla and Thomas Arzberger and Alfredo Milone and Marco Losa and Vincenzo Di Marzo and Beat Lutz and Guenter Karl Stalla},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2001},
  volume={86 6},
  pages={2687-96}
}
Little is known about the expression and function of cannabinoid receptor type 1 (CB1) in the human pituitary gland. The aim of this study was to investigate CB1 expression in human normal and tumoral pituitaries by in situ hybridization and immunohistochemistry using an antibody against CB1. CB1 was found in corticotrophs, mammotrophs, somatotrophs, and folliculostellate cells in the anterior lobe of normal pituitary. After examination of 42 pituitary adenomas, CB1 was detected in acromegaly… CONTINUE READING
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