Normal human chromosomes have long G-rich telomeric overhangs at one end.

@article{Wright1997NormalHC,
  title={Normal human chromosomes have long G-rich telomeric overhangs at one end.},
  author={W. Wright and V. M. Tesmer and K. Huffman and S. Levene and J. Shay},
  journal={Genes & development},
  year={1997},
  volume={11 21},
  pages={
          2801-9
        }
}
Telomeres protect the ends of linear chromosomes from degradation and abnormal recombination events, and in vertebrates may be important in cellular senescence and cancer. However, very little is known about the structure of human telomeres. In this report we purify telomeres and analyze their termini. We show that following replication the daughter telomeres have different terminal overhangs in normal diploid telomerase-negative human fibroblasts. Electron microscopy of those telomeres that… Expand
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