Normal hematopoiesis is maintained by activated bone marrow CD4+ T cells.

@article{Monteiro2005NormalHI,
  title={Normal hematopoiesis is maintained by activated bone marrow CD4+ T cells.},
  author={Joao Monteiro and Aline Benjamin and Elaine S. Costa and Marcello Andr{\'e} Barcinski and Adriana Bonomo},
  journal={Blood},
  year={2005},
  volume={105 4},
  pages={1484-91}
}
CD4(+) T cells produce hematopoietic-related cytokines and are essential for hematopoiesis stimulation during infection and hematologic recovery after bone marrow transplantation. However, it remains unclear if T cells are necessary to maintain normal hematopoiesis. We report here that, in T-cell-deficient mice, terminal differentiation of myeloid progenitors is defective, resulting in very low levels of granulocytes in the periphery. Hematopoiesis is restored after thymus graft or… CONTINUE READING

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