Normal hematopoiesis is maintained by activated bone marrow CD4+ T cells.

  title={Normal hematopoiesis is maintained by activated bone marrow CD4+ T cells.},
  author={Joao Monteiro and Aline Benjamin and Elaine S. Costa and Marcello Andr{\'e} Barcinski and Adriana Bonomo},
  volume={105 4},
CD4(+) T cells produce hematopoietic-related cytokines and are essential for hematopoiesis stimulation during infection and hematologic recovery after bone marrow transplantation. However, it remains unclear if T cells are necessary to maintain normal hematopoiesis. We report here that, in T-cell-deficient mice, terminal differentiation of myeloid progenitors is defective, resulting in very low levels of granulocytes in the periphery. Hematopoiesis is restored after thymus graft or… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 50 extracted citations


Publications referenced by this paper.
Showing 1-10 of 60 references

dritic cells signal T cells in the absence of exogenous antigen

  • T Kondo, I Cortese, S Plese
  • Nature Immunol
  • 2002

Similar Papers

Loading similar papers…