Normal growth in a patient with septo-optic dysplasia despite both growth hormone and IGF-I deficiency.

@article{Bereket1998NormalGI,
  title={Normal growth in a patient with septo-optic dysplasia despite both growth hormone and IGF-I deficiency.},
  author={Abdullah Bereket and Charles H Lang and Mitchell E Geffner and Thomas A. Wilson},
  journal={Journal of pediatric endocrinology & metabolism : JPEM},
  year={1998},
  volume={11 1},
  pages={
          69-75
        }
}
A 17 year-old female with septo-optic dysplasia (SOD) and hypopituitarism who has grown normally despite GH deficiency is presented. Her serum was examined to test current hypotheses to explain the phenomenon of growth without GH. The patient's serum possessed potent in vitro growth-promoting activity (GPA) in an erythroid progenitor-cell clonal proliferation assay consistent with the patient's normal growth performance. In contrast to previously reported cases of growth without GH, total IGF-I… CONTINUE READING
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