Normal disposition of oxazepam in acute viral hepatitis and cirrhosis.

  title={Normal disposition of oxazepam in acute viral hepatitis and cirrhosis.},
  author={H J Shull and Grant R. Wilkinson and Raymond F Johnson and Steven Schenker},
  journal={Annals of internal medicine},
  volume={84 4},
Oxazepam (Serax) is a tranquilizer-sedative of the benzodiazepine group that is predominantly metabolized to a pharmacologically inactive glucuronide and subsequently excreted by way of the kidneys. We administered this drug as a single oral dose to seven patients with acute viral hepatitis, to six with cirrhosis, and to age-matched control subjects. Elimination half-life (T1/2) and the apparent oral plasma clearance for the drug in patients with hepatitis and cirrhosis were comparable to… CONTINUE READING


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