Normal diploid human and rodent cells lack a detectable frequency of gene amplification.

  title={Normal diploid human and rodent cells lack a detectable frequency of gene amplification.},
  author={Thea D. Tlsty},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={87 8},
  • Thea D. Tlsty
  • Published 1990 in
    Proceedings of the National Academy of Sciences…
Gene amplification is frequently observed in tumors and transformed cell lines. This phenomenon is known to contribute to the generation of drug-resistant tumor cells and quantitation of the event is believed to have prognostic value in several types of neoplasias. To date, most studies of gene amplification have used immortalized cell lines and biopsied tumor samples. In this study I examine the amplification potentials of primary diploid cells, both human and rodent, and quantitatively… CONTINUE READING
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