Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout.

@article{Doi1999NormalDO,
  title={Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout.},
  author={Yoshinori Doi and Makoto Itoh and Shigenobu Yonemura and Saki Ishihara and Hirokuni Takano and Tetsuo Noda and Shoichiro Tsukita},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 4},
  pages={2315-21}
}
Ezrin/radixin/moesin (ERM) proteins are general cross-linkers between the plasma membrane and actin filaments. Because their expression is regulated in a tissue-specific manner, each ERM protein has been proposed to have unique functions. On the other hand, experiments at the cellular level and in vitro have suggested their functional redundancy. To assess the possible unique functions of ERM proteins in vivo, the moesin gene located on the X chromosome was disrupted by gene targeting in… CONTINUE READING

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