Normal cytotoxic response of skin fibroblasts from patients with Li-Fraumeni familial cancer syndrome to DNA-damaging agents in vitro.

@article{Little1987NormalCR,
  title={Normal cytotoxic response of skin fibroblasts from patients with Li-Fraumeni familial cancer syndrome to DNA-damaging agents in vitro.},
  author={J. B. Little and John Nove and William K. Dahlberg and Philip J. Troilo and Warren W. Nichols and Lynn Curtis Strong},
  journal={Cancer research},
  year={1987},
  volume={47 15},
  pages={
          4229-34
        }
}
Skin fibroblasts from patients with the Li-Fraumeni familial cancer syndrome have been reported to show abnormalities in their response to X-irradiation. We have examined the response of fibroblasts from affected and nonaffected individuals in three families to treatment with four DNA-damaging agents: X-rays, UV light, N-methyl-N'-nitro-N-nitrosoguanidine, and mitomycin C. Test cells along with additional cell bank control strains were received coded and blinded. The same strains were studied… CONTINUE READING

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