Normal cortisol response to high-dose synacthen and insulin tolerance test in children and adults with Prader-Willi syndrome.

@article{Farholt2011NormalCR,
  title={Normal cortisol response to high-dose synacthen and insulin tolerance test in children and adults with Prader-Willi syndrome.},
  author={Stense Farholt and Rasmus Sode-Carlsen and Jens Sandahl Christiansen and John Rosendahl \Ostergaard and Charlotte H\oybye},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2011},
  volume={96 1},
  pages={E173-80}
}
CONTEXT Prader-Willi syndrome (PWS) is a genetic disease associated with hypogonadism and partial GH insufficiency, possibly explained in part by a hypothalamic dysfunction. Partial insufficiency of the hypothalamic-pituitary-adrenal (HPA) axis has recently been suggested. OBJECTIVE The objective of the study was to further explore the HPA axis in PWS by use of routine tests. DESIGN Nonselected PWS patients were examined with a standard high-dose synacthen test or the insulin tolerance test… CONTINUE READING