Normal colorectal mucosa exhibits sex- and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters

@article{Menigatti2009NormalCM,
  title={Normal colorectal mucosa exhibits sex- and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters},
  author={Mirco Menigatti and Kaspar Truninger and Jan O Gebbers and Urs Albert Marbet and Giancarlo Marra and Primo Sch{\"a}r},
  journal={Oncogene},
  year={2009},
  volume={28},
  pages={899-909}
}
Silencing of gene expression by aberrant cytosine methylation is a prominent feature of human tumors, including colorectal cancers. Epigenetic changes of this type play undisputed roles in cell transformation when they involve genes that safeguard genome stability, and they can also be detected in precancerous lesions and seemingly normal peritumoral tissues. We explored physiological conditions associated with aberrant promoter methylation involving two DNA-repair genes in normal colorectal… CONTINUE READING
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