Normal calves produced after transfer of in vitro fertilized embryos cultured with an antiviral compound.

@article{Givens2006NormalCP,
  title={Normal calves produced after transfer of in vitro fertilized embryos cultured with an antiviral compound.},
  author={M. Daniel Givens and David A. Stringfellow and Kay P. Riddell and Patricia K. Galik and Robert L. Carson and M. Gatz Riddell and Christine B. Navarre},
  journal={Theriogenology},
  year={2006},
  volume={65 2},
  pages={
          344-55
        }
}
Bovine viral diarrhea virus (BVDV) replicates in embryo co-culture systems and remains associated with developing IVF bovine embryos, despite washing and trypsin treatment. Previous research demonstrated that 2-(4-[2-imidazolinyl]phenyl)-5-(4-methoxyphenyl)furan (DB606) inhibits replication of BVDV in cultured cells. The objective of this study was to evaluate the capability of IVF embryos to develop into normal, weaned calves after exposure to antiviral concentrations of DB606 during IVC… 
Normal reproductive capacity of heifers that originated from in vitro fertilized embryos cultured with an antiviral compound.
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Results indicate that culture of bovine-IVF embryos in DB606 does not impair future reproductive capacity of resulting heifers.
Normal calves produced after transfer of embryos cultured in a chemically defined medium supplemented with epidermal growth factor and insulin-like growth factor I following ovum pick up and in vitro fertilization in Japanese black cows.
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It is suggested that the combined use of EGF and IGF-I makes bovine embryo culture in a chemically defined medium a practical and useful procedure for producing blastocysts, and its application to embryo culture following ovum pick up and in vitro fertilization could be useful for producing normal calves.
Risk assessment of transmission of bovine viral diarrhea virus (BVDV) in abattoir-derived in vitro produced embryos.
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  • 2007
TLDR
To estimate the risk of producing infected recipients and persistently infected calves from abattoir-derived IVP embryos, a quantitative risk assessment model using Microsoft Excel and Palisade @Risk was developed and assumed some of the complexities of the IVP process.
Interferência da infecção experimental pelo vírus da diarréia viral bovina (BVDV) na eficácia da produção in vitro de embriões bovinos
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BVDV presence during in vitro maturation (IVM) of bovine cumuli oophorus complexes (COCs) and this affects their expansion pattern, which may be related to the observed reduced nuclear maturation and blastocyst development rates.
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Although the use of co-culture in clinical practice is unacceptable and its implementation in domestic species for commercial purposes should be viewed with diffidence, this technique can still provide a wealth of information on the development of novel, more physiological embryo in vitro culture systems.
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TLDR
An overview of the risks of transmitting this virus by AI or production and transfer of embryos and summarizes the precautions needed to prevent such transmissions of disease from occurring is provided.
Disinfection procedures for controlling microorganisms in the semen and embryos of humans and farm animals.
TLDR
None can be recommended as a universal disinfection method for rendering semen and embryos free from all potentially pathogenic microorganisms, and some procedures are unsuitable, as they can compromise the viability of semen or embryos.
Antiviral Treatment of Calves Persistently Infected with Bovine Viral Diarrhoea Virus
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Results demonstrate that DB772 administration is safe and exhibits antiviral properties in PI calves while facilitating the rapid development of viral resistance to this novel therapeutic agent.
Evaluation of the effectiveness of semen processing techniques to remove bovine viral diarrhea virus from experimentally contaminated semen samples.
TLDR
The data showed that the combination of Swim up/Percoll gradient centrifugation promoted the elimination of BVDV from the semen samples without damaging spermatozoa cells and also allowed successful in vitro embryo production free of BVBV.
Emerging diseases in international trade in embryos
TLDR
The embryo transfer industry has reached a new record of growth, with approximately 1.5 million transferrable bovine embryos collected and/or produced in 2018, over 1 million of these embryos were produced in vitro.
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TLDR
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