Normal calves produced after transfer of in vitro fertilized embryos cultured with an antiviral compound.

  title={Normal calves produced after transfer of in vitro fertilized embryos cultured with an antiviral compound.},
  author={M. Givens and D. Stringfellow and K. Riddell and P. Galik and R. Carson and M. Riddell and C. Navarre},
  volume={65 2},
  • M. Givens, D. Stringfellow, +4 authors C. Navarre
  • Published 2006
  • Biology, Medicine
  • Theriogenology
  • Bovine viral diarrhea virus (BVDV) replicates in embryo co-culture systems and remains associated with developing IVF bovine embryos, despite washing and trypsin treatment. Previous research demonstrated that 2-(4-[2-imidazolinyl]phenyl)-5-(4-methoxyphenyl)furan (DB606) inhibits replication of BVDV in cultured cells. The objective of this study was to evaluate the capability of IVF embryos to develop into normal, weaned calves after exposure to antiviral concentrations of DB606 during IVC… CONTINUE READING
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