Normal atrial natriuretic peptide release after acute and chronic stimuli in hypophysectomized rats.

@article{Hoffman1989NormalAN,
  title={Normal atrial natriuretic peptide release after acute and chronic stimuli in hypophysectomized rats.},
  author={Amnon Hoffman and Harry R. Keiser},
  journal={The American journal of physiology},
  year={1989},
  volume={257 3 Pt 2},
  pages={
          R522-7
        }
}
To test the hypothesis that the pituitary gland has a role in modulating the release of atrial natriuretic peptide (ANP) from atrial myocytes, we applied different stimuli of both acute and chronic nature to rats 8-10 days after hypophysectomy (Hypx). Acute rapid cardiac pacing at a rate of 500 beats/min in anesthetized rats caused a marked increase in plasma levels of ANP (from 76 +/- 7 to 237 +/- 60 pg/ml, P less than 0.05) despite a marked decrease of blood pressure. This response was… CONTINUE READING
BETA