Normal and malignant human urothelium: in vitro response to blockade of polyamine synthesis and interconversion.

  title={Normal and malignant human urothelium: in vitro response to blockade of polyamine synthesis and interconversion.},
  author={Edward Messing and Piia T Hanson and Catherine A. Reznikoff},
  journal={Cancer research},
  volume={48 2},
To assess the effect of polyamine blockade on urinary epithelium, growth of normal human urothelial cell cultures and human transitional cell carcinoma (TCC) cell lines in the presence of various inhibitors of polyamine synthesis was evaluated. All four human TCC cell lines tested were quite sensitive to the specific inhibitor of ornithine decarboxylase, alpha-difluoromethylornithine (DFMO), requiring less than or equal to 1.0 mM DFMO to double generation time. Alternatively, all three human… CONTINUE READING
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