Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: an in vitro study relevant to bone marrow purging.

@article{Calabretta1991NormalAL,
  title={Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: an in vitro study relevant to bone marrow purging.},
  author={Bruno Calabretta and Robert Brownell Sims and Mauro Valtieri and Daniele Caracciolo and Rachel Grossman and Donatella Venturelli and Mariusz Z. Ratajczak and Max A. Beran and Alan M. Gewirtz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 6},
  pages={
          2351-5
        }
}
The c-myb protooncogene is preferentially expressed in hematopoietic cells, and its encoded protein, Myb, is required for hematopoietic cell proliferation. To analyze the relative Myb dependence of normal and leukemic human hematopoietic progenitor cells, normal bone marrow cells, several types of leukemic blast cells, and 1:1 mixtures of normal and leukemic cells were cultured in the presence of c-myb sense or antisense oligodeoxynucleotides; cell viability and cloning efficiency were then… CONTINUE READING
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