Normal and leukaemic haematopoiesis in bone marrow and peripheral blood of patients with chronic myeloid leukaemia.

@article{Frassoni1999NormalAL,
  title={Normal and leukaemic haematopoiesis in bone marrow and peripheral blood of patients with chronic myeloid leukaemia.},
  author={Francesco Frassoni and Marina Podest{\`a} and Giovanna Piaggio},
  journal={Bailliere's best practice & research. Clinical haematology},
  year={1999},
  volume={12 1-2},
  pages={
          199-208
        }
}
In the majority of newly diagnosed patients with chronic myeloid leukaemia (CML), the bone marrow contains consistent numbers of normal Ph-negative surrogate stem cells (LTC-IC) which seem to decline rapidly with time. This is confirmed by mobilization studies showing that early after diagnosis is the optimal time to collect Ph-negative progenitor to be utilized for restoring Ph-negative haematopoiesis. In the marrow of the majority of CML patients at diagnosis Ph-positive LTC-IC are found at a… CONTINUE READING
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