Normal and high eNOS levels are detrimental in both mild and severe cardiac pressure-overload.

@article{Deel2015NormalAH,
  title={Normal and high eNOS levels are detrimental in both mild and severe cardiac pressure-overload.},
  author={Elza D van Deel and Yanti Octavia and Martine de Boer and Rio Putra Juni and Dennie Tempel and Rien van Haperen and Rini de Crom and An L. Moens and Daphne Merkus and Dirk Jan Duncker},
  journal={Journal of molecular and cellular cardiology},
  year={2015},
  volume={88},
  pages={
          145-54
        }
}
Nitric oxide (NO) produced by endothelial NO synthase (eNOS) exerts beneficial effects in a variety of cardiovascular disease states. Studies on the benefit of eNOS activity in pressure-overload cardiac hypertrophy and dysfunction produced by aortic stenosis are equivocal, which may be due to different expression levels of eNOS or different severities of pressure-overload. Consequently, we investigated the effects of eNOS-expression level on cardiac hypertrophy and dysfunction produced by mild… CONTINUE READING
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