Normal and abnormal development of the intrapericardial arterial trunks in humans and mice.

  title={Normal and abnormal development of the intrapericardial arterial trunks in humans and mice.},
  author={Robert H. Anderson and Bill Chaudhry and Timothy Mohun and Simon D. Bamforth and Darren Hoyland and Helen M. Phillips and Sandra Webb and Antoon F. M. Moorman and Nigel Brown and Deborah J Henderson},
  journal={Cardiovascular research},
  volume={95 1},
AIMS The definitive cardiac outflow channels have three components: the intrapericardial arterial trunks; the arterial roots with valves; and the ventricular outflow tracts (OFTs). We studied the normal and abnormal development of the most distal of these, the arterial trunks, comparing findings in mice and humans. METHODS AND RESULTS Using lineage tracing and three-dimensional visualization by episcopic reconstruction and scanning electron microscopy, we studied embryonic day 9.5-12.5 mouse… CONTINUE READING
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