Normal activities of hepatic pyruvate dehydrogenase and pyruvate carboxylase in Leigh's syndrome.

@article{Tsuchiyama1983NormalAO,
  title={Normal activities of hepatic pyruvate dehydrogenase and pyruvate carboxylase in Leigh's syndrome.},
  author={Akira Tsuchiyama and Kazuhiko Oyanagi and Hideaki Sogawa and Toshiyuki Nakao and Kazuei Ogawa and Shuichi Fujita},
  journal={The Tohoku journal of experimental medicine},
  year={1983},
  volume={139 1},
  pages={67-72}
}
A case of Leigh's syndrome (subacute necrotizing encephalomyelopathy, SNE), proven by autopsy, was reported. The persistent elevation of pyruvate and lactate in blood and hyperalanemia suggested an impairment of pyruvate oxidation, but the enzyme activities of pyruvate dehydrogenase (PDH) and pyruvate carboxylase (PC) in liver tissues of the patient… CONTINUE READING