Normal Phototransduction in Drosophila Photoreceptors Lacking an InsP3 Receptor Gene

@article{Raghu2000NormalPI,
  title={Normal Phototransduction in Drosophila Photoreceptors Lacking an InsP3 Receptor Gene},
  author={Padinjat Raghu and Nansi Jo Colley and Rebecca Webel and Tracy James and Gaiti Hasan and Michal Danin and Zvi Selinger and Roger C. Hardie},
  journal={Molecular and Cellular Neuroscience},
  year={2000},
  volume={15},
  pages={429-445}
}
The Drosophila light-sensitive channels TRP and TRPL are prototypical members of an ion channel family responsible for a variety of receptor-mediated Ca(2+) influx phenomena, including store-operated calcium influx. While phospholipase Cbeta is essential, downstream events leading to TRP and TRPL activation remain unclear. We investigated the role of the InsP(3) receptor (InsP(3)R) by generating mosaic eyes homozygous for a deficiency of the only known InsP(3)R gene in Drosophila. Absence of… Expand
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