Normal Phototransduction in Drosophila Photoreceptors Lacking an InsP3 Receptor Gene

@article{Raghu2000NormalPI,
  title={Normal Phototransduction in Drosophila Photoreceptors Lacking an InsP3 Receptor Gene},
  author={Padinjat Raghu and Nansi Jo Colley and Rebecca Webel and Tracy James and Gaiti Hasan and Michal Danin and Zvi Selinger and Roger C. Hardie},
  journal={Molecular and Cellular Neuroscience},
  year={2000},
  volume={15},
  pages={429-445}
}
The Drosophila light-sensitive channels TRP and TRPL are prototypical members of an ion channel family responsible for a variety of receptor-mediated Ca(2+) influx phenomena, including store-operated calcium influx. While phospholipase Cbeta is essential, downstream events leading to TRP and TRPL activation remain unclear. We investigated the role of the InsP(3) receptor (InsP(3)R) by generating mosaic eyes homozygous for a deficiency of the only known InsP(3)R gene in Drosophila. Absence of… 
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References

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TLDR
The results indicate that the response inactivation in trp cells results from Ca2+ deficiency rather than from Ca(2+)-dependent negative feedback, and indicate that there is light-induced release of Ca 2+ from intracellular stores.
Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL
TLDR
It is suggested that another polyunsaturated fatty acid, such as linolenic acid, may be a messenger of excitation in Drosophila photoreceptors, as four different lipoxygenase inhibitors, which might be expected to lead to build-up of endogenous fatty acids, also activate native TRP and TRPL channels in intact photoresceptors.
Photolysis of caged Ca2+ facilitates and inactivates but does not directly excite light-sensitive channels in Drosophila photoreceptors
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  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
TLDR
Caged Ca2+ failed to activate any channels in Drosophila photoreceptors but profoundly affected the light-dependent channels once they have been activated.
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