Normal Fibroblasts Induce E-Cadherin Loss and Increase Lymph Node Metastasis in Gastric Cancer

Abstract

BACKGROUND A tumor is considered a heterogeneous complex in a three-dimensional environment that is flush with pathophysiological and biomechanical signals. Cell-stroma interactions guide the development and generation of tumors. Here, we evaluate the contributions of normal fibroblasts to gastric cancer. METHODOLOGY/PRINCIPAL FINDINGS By coculturing… (More)
DOI: 10.1371/journal.pone.0097306

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Cite this paper

@inproceedings{Xu2014NormalFI, title={Normal Fibroblasts Induce E-Cadherin Loss and Increase Lymph Node Metastasis in Gastric Cancer}, author={Wen Xu and Xinlei Hu and Zhongting Chen and Xiaoping Zheng and Chenjing Zhang and Gang Wang and Yu Chen and Xinglu Zhou and Xiaoxiao Tang and Laisheng Luo and Xiang Xu and Wensheng Pan}, booktitle={PloS one}, year={2014} }