Normal B Cell Homeostasis Requires B Cell Activation Factor Production by Radiation-resistant Cells

@article{Gorelik2003NormalBC,
  title={Normal B Cell Homeostasis Requires B Cell Activation Factor Production by Radiation-resistant Cells},
  author={Leonid Gorelik and Kevin J Gilbride and Max Dobles and Susan L. Kalled and Daniel B Zandman and Martin L. Scott},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={198},
  pages={937 - 945}
}
The cellular source of B cell activation factor (BAFF) required for peripheral B cell survival/maturation is unknown. To determine the nature of BAFF-producing cells we established and analyzed reciprocal bone marrow (BM) chimeras with wild-type (WT) and BAFF-deficient mice. The results revealed that BAFF production by radiation-resistant stromal cells is completely sufficient to provide a necessary signal for B cell survival/maturation, as BAFF-/- BM cells transferred into lethally irradiated… CONTINUE READING
106 Citations
29 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 106 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Similar Papers

Loading similar papers…