Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases.

Abstract

Leukemias expressing constitutively activated mutants of ABL1 tyrosine kinase (BCR-ABL1, TEL-ABL1, NUP214-ABL1) usually contain at least 1 normal ABL1 allele. Because oncogenic and normal ABL1 kinases may exert opposite effects on cell behavior, we examined the role of normal ABL1 in leukemias induced by oncogenic ABL1 kinases. BCR-ABL1-Abl1(-/-) cells… (More)
DOI: 10.1182/blood-2015-11-681171

Topics

6 Figures and Tables

Cite this paper

@article{Dasgupta2016NormalAI, title={Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases.}, author={Yashodhara Dasgupta and Mateusz Koptyra and Grazyna Anna Hoser and Kanchan Kantekure and Darshan B Roy and Barbara G{\'o}rnicka and Margaret Nieborowska-Skorska and Elisabeth Bolton-Gillespie and Sabine Cerny-Reiterer and Markus M{\"{u}schen and Peter Valent and Mariusz A Wasik and Christine A. Richardson and Oliver Hantschel and Heiko van der Kuip and Tomasz Stoklosa and Tomasz Sk{\'o}rski}, journal={Blood}, year={2016}, volume={127 17}, pages={2131-43} }