Normal, benign, preneoplastic, and malignant prostate cells have distinct protein expression profiles resolved by surface enhanced laser desorption/ionization mass spectrometry.

@article{Cazares2002NormalBP,
  title={Normal, benign, preneoplastic, and malignant prostate cells have distinct protein expression profiles resolved by surface enhanced laser desorption/ionization mass spectrometry.},
  author={Lisa H. Cazares and Bao-Ling Adam and Michael D. Ward and Suhail Nasim and Paul F. Schellhammer and O. John Semmes and George L. Wright},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2002},
  volume={8 8},
  pages={2541-52}
}
PURPOSE The objective of this study was to discover protein biomarkers that differentiate malignant from nonmalignant cell populations, especially early protein alterations that signal the initiation of a developing cancer. We hypothesized that Surface Enhanced Laser Desorption/Ionization-time of flight-mass spectrometry-assisted protein profiling could detect these protein alterations. EXPERIMENTAL DESIGN Epithelial cell populations [benign prostatic hyperplasia (BPH), prostate… CONTINUE READING