Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation in Staphylococcus aureus

@inproceedings{Baldry2016NorlichexanthoneRV,
  title={Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation in Staphylococcus aureus},
  author={Mara Baldry and Anita Nielsen and Martin Saxtorph Bojer and Yu Zhao and Cathrine Friberg and Dan Ifrah and Nina Glasser Heede and Thomas Ostenfeld Larsen and Hanne Fr\oki{\ae}r and Dorte Frees and Lixin Zhang and Huanqin Dai and Hanne Ingmer},
  booktitle={PloS one},
  year={2016}
}
Staphylococcus aureus is a serious human pathogen and antibiotic resistant, community-associated strains, such as the methicillin resistant S. aureus (MRSA) strain USA300, continue to spread. To avoid resistance, anti-virulence therapy has been proposed where toxicity is targeted rather than viability. Previously we have shown that norlichexanthone, a small non-reduced tricyclic polyketide produced by fungi and lichens, reduces expression of hla encoding α-hemolysin as well as the regulatory… CONTINUE READING